49ers TE George Kittle expected to be out multiple weeks with hamstring injury, QB Brock Purdy dealing with shoulder and toe injuries

49ers TE George Kittle expected to be out multiple weeks with hamstring injury, QB Brock Purdy dealing with shoulder and toe injuries Ryan YoungSeptember 8, 2025 at 11:58 PM 0 George Kittle left Sunday's win over the Seahawks early with a hamstring injury.

- - 49ers TE George Kittle expected to be out multiple weeks with hamstring injury, QB Brock Purdy dealing with shoulder and toe injuries

Ryan YoungSeptember 8, 2025 at 11:58 PM

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George Kittle left Sunday's win over the Seahawks early with a hamstring injury. (AP/John Froschauer) ()

The San Francisco 49ers offense is extremely banged up after their season-opener.

49ers tight end George Kittle is expected to be sidelined for up to five weeks after he left Sunday's 17-13 win over the Seattle Seahawks with a hamstring injury, according to the NFL Network's Ian Rapoport. That makes Kittle a candidate to land on injured reserve, which would sideline him for at least four weeks.

Kittle left Sunday's game at Lumen Field in the second quarter, and he was ruled out with the hamstring injury shortly before halftime. It's unclear when exactly he injured his hamstring, though he had four catches for 25 yards and made a 5-yard touchdown grab to put the team up early.

The former Iowa standout had 1,106 receiving yards and eight touchdowns last season, his eighth in the league with the 49ers. Kittle signed a four-year, $76.4 million extension with the 49ers in April that will keep him with the franchise through the 2029 campaign.

Though he didn't leave the game early, Purdy also sustained multiple injuries on Sunday. He is now dealing with both a toe injury and a shoulder injury, coach Kyle Shanahan confirmed on Monday. Specifics of both injuries are not yet known, but Shanahan said Purdy's toe injury is worse than his shoulder injury. The team hopes to have clarity on his status later this week.

Purdy went 26-of-35 for 227 yards with two touchdowns and two interceptions in Sunday's win. He scrambled and completed a late touchdown pass to Jake Tonges with about 90 seconds left in the game to lift the 49ers to the win, too.

The 49ers will host the New Orleans Saints next on Sunday. If Purdy is unable to play in that contest, backup Mac Jones will be the next man up. Jones signed a two-year deal to join the 49ers this past offseason.

Kittle, assuming he lands on injured reserve after all, will be out until mid-October. Though Purdy isn't expected to be out anywhere near as long, those two injuries to key offense players isn't a great sign this early in the season.

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Source: "AOL AOL Sports"

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